![]() Sieve analysis equipment is relatively inexpensive, and it is still widely used at line and for quality control purposes. Laser diffraction and sieve analysis are commonly used techniques to measure granule particle size post-milling. Polymers with various physical properties (such as solubility, molecular weight, reactivity, viscosity, biodegradability, permeability, and so on) have been applied to create microparticles 19, 20, 21, 22. The hardening speed of microparticles in the solvent evaporation cycle is affected by the solubility of the polymer in organic solvents, which impact on microparticle properties such as particle size, volume of encapsulated drugs, matrix porosity, solvent residues, and initial drug release 16, 17, 18, 19. Slow hardening of droplets or emulsions causes drug compound diffusion, resulting in poor encapsulation content 1, 3, 12, 13, 14, 15. When using solvent evaporation techniques to prepare microparticles, the hardening speed of microparticles is a crucial factor that significantly affects drug release 3. Thus, it is necessary to know the effect of polymer properties on the polymeric microparticle hardening time as well as solidification rate. According to Mehta et al., solubilities of polymers in organic solvents determine the solidification rate of the polymers during the microparticle preparation process, which in turn affects microparticle properties such as particle size 13. The solidification rate of polymeric microparticles is also an important parameter influencing the particle size, the encapsulation efficiency and the initial burst in microparticulate systems. Information about the microparticle hardening rate which is an important factor in determining particle size from these polymers is not available. They are poly(є-caprolactone), poly(lactic-co-glycolic acid), copolymers of ethyl acrylate, and ethyl cellulose 5, 6, 7, 8, 10, 11, 12. ![]() ![]() Various types of polymer with different physical properties (such as biodegradable, non-biodegradable, permeable, etc.) have been used in microparticles preparation. Microparticles have been prepared with a wide range of polymers and polymer blends 1, 2. Water insoluble polymers are usually used as encapsulation matrix for these microparticles. Solvent evaporation method is a popular technique for the encapsulation of drugs within polymeric microparticles. The requirement to ensure the manufacture of a repeatable product necessitates the ability to produce microparticulate particle sizes and distributions within defined limits 1, 2, 3, 4, 5. Microparticle friability, microparticle flowability, tablet weight variance, tabletability, microparticle bulk density, tablet porosity, and tablet dissolution rate are all important parameters to be considered 1, 2, 3, 4, 5. Microencapsulation is a typical unit operation used in the production of solid dosage types including tablets, capsules, and sachets. The FBRM data revealed that the polymer type had a significant impact on microparticle CLD and the transformation process. The FBRM CLDs revealed that a larger particle size mean resulted in a longer CLD and a lower peak of particle number. Hardening time for the transformation of emulsion droplets into solid microparticles occurred within the first 10.5, 19, 25, 30, and 55 min, according to FBRM results. For all three produced batches tested, FBRM, laser diffraction, and sieve analysis yielded similar results. The timing of the FBRM determinations was coordinated with the selection of microparticle samples for particle size analysis by optical microscope and laser diffraction calculation as a reference. The chord lengths and CLD data were taken at specific times using an online FBRM probe mounted below the microparticle. FBRM was also utilized to measure the length-weighted chord length distribution (CLD) and particle size distribution (PSD) online during particle solidification, which could not be done with laser diffraction or nested sieve analysis. ![]() In this paper, we use FBRM measurements to investigate the effects of polymer type and compare the size distributions to those obtained using other sizing methods such as optical microscope and laser diffraction. The online real-time particle size analysis of the microencapsules manufacturing process using the continuous solvent evaporation method was performed using focused beam reflectance measurement (FBRM).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |